Building a better mouse means better testing for cutting edge therapies

Please note that the NCG and Humanized NCG models referenced in the video are available through Charles River in North America only.

In the earliest days of humanized mice, researchers used strains of “nude mice” whose mutation caused them to lack a thymus. For two decades these mice were the cutting edge of human immune deficiency disease research, including work on leukemia and AIDS. In 1983, severe combined immunodeficient (SCID) mice were discovered, which boasted even more severely diminished immune systems. 

When genetic engineering hit the scene, immune deficient mice could be endowed with rudimentary, human-like immune systems. As the decades have progressed, these “humanized” mice have grown in popularity and complexity, allowing researchers to gain valuable insight into the safety and efficacy of their experimental drugs before moving on to clinical trials. 

As recently as this year, Charles River is rolling out new humanized mouse strains. Each generation of humanized mice has offered new features and benefits, along with considerations for which type of studies they are best suited for. 

Product Manager Carina Peritore agreed to interview scientists Jenny Rowe and Christoph Eberle about these new mice. Watch now to learn about the development of these valuable research models.