The average person might not consider the skeleton an endocrine organ, but in fact it is important in regulating metabolism, muscles, the reproductive system, even the immune system where the composition of the gut microbiome appears to play a role in how we handle disease.Susan Smith, Senior Scientific Director at Charles River Canada, center, talks with Principal Scientists Rana Samadfam, left, and Aurore Varela talk about the synergy of bones and energy metabolism at the Society of Toxicology Meeting held in Phoenix March 23-26.