Anne-Marie is the Associate Director Genome Engineering at Charles River. She has been active as project leader in a CRO environment managing projects in the field of fibrosis, arthritis, metabolic syndrome, and the central nervous system for more than 11 years. The nature of these projects ranged from target discovery using RNA interference, in vitro and in vivo target validation using viral systems for shRNA delivery to mechanistic and compound efficacy studies in animal models of disease. She was responsible for the implementation of the CRISPR/Cas9 technology in the drug discovery and animal research models divisions of Charles River since she joined the company in January 2015 and is now leading genome engineering projects using this technology to support in vitro drug discovery. She earned her doctoral degree in molecular biology and MSc in biology from University of Leiden.