- May 13, 2013 | BY
Chronic hyperglycemia is associated with multiple end organ complications and fatty liver. Less often recognized is the long term effect of high glucose on the skeleton.
- May 8, 2013 | BY
If you have been following public health issues you have a pretty good appreciation for the world’s greatest public health problem: the epidemic of obesity-related diseases.
- April 23, 2013 | BY
Conserving animals through proper reduction strategies, while also protecting humans in the long run, can be a difficult balance. A strong commitment to 3Rs helps.
- April 16, 2013 | BY
We’re always looking for better ways to provide good welfare for animals in our care, but how do we always know environmental enrichments improve the welfare of animals?
- April 1, 2013 | BY
The 3Rs proposed by scientists Russell and Burch in the 1950s set the standard for minimizing animal use and maximizing animal well-being in laboratory experimentation.
- March 26, 2013 | BY
The clinical effects of drugs on cardiac repolarization and rhythm, particularly the induction of potentially fatal arrhythmias, such as Torsade de Pointes (TdP), have been increasingly documented over the past two decades. These concerns have given rise to specific regulatory measures, such the ICH S7A, S7B and E14 guidance. These, in turn, have given rise ...
- March 18, 2013 | BY
Jacketed external telemetry (JET) is the latest technology available for collection of continuous electrocardiograms (ECGs) from unrestrained animals. It delivers higher‑quality cardiovascular safety data than predecessor external technologies and has become a premier solution for preclinical research without the use of invasive implantation techniques. After all, Cardiovascular Safety Pharmacology is a logical target as a ...
- March 12, 2013 | BY
Many drugs have either been withdrawn from the market or placed on restricted use due to their (or their metabolites) undesirable ‘off-target’ effects on the heart. An increase in the cardiac action potential duration (APD), caused by a drug blocking the hERG (human ether a go-go) ion channel, can be defined by a prolongation of ...
- March 4, 2013 | BY
The harmonization of regulatory guidance for drug development traces its origins to the European Community (EC) in the mid 1980’s. The current governing body of record, known as the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH), was formed in 1990 at a joint meeting of regulatory agencies ...
- February 25, 2013 | BY
When I hear the word anticipation, I can’t help but think of the first line in the song with the same title that Carly Simon made famous in the 1970’s: “We can never know about the days to come.”
That is where we are with the long-anticipated modernization of the Food and Drug Administration (FDA) Good ...