- August 27, 2012 | BY
With its many anatomical, physiological and functional similarities to humans, the miniature pig (minipig, Sus scrofa) has become a viable alternative to non-rodent animal models in nonclinical safety testing.
- August 14, 2012 | BY
Ipilimumab and other cancer biologics like it are based on natural antibodies, slightly changed to give them the long-acting characteristics of the natural form as well as the ability to target proteins on specific cells.
- August 8, 2012 | BY
While photosafety testing has been an important part of preclinical drug development for over 30 years, it’s poorly understood as to the accepted methodologies, when to initiate evaluation, the expectations of the regulatory agencies, and how to interpret results. The lack of clarity in current regulatory guidances, controversy over the interpretation of in vitro assays ...
- July 30, 2012 | BY
Medulloblastoma, a cancer of the central nervous system, is the most common brain malignancy in children, accounting for 15-20% of tumors.
- July 23, 2012 | BY
Even with improved housing and health monitoring, positive serologic or culture findings for microorganisms can and do happen in animal facilities. And as much as an animal facility wants negative laboratory results for all agents on an exclusion list, bacteria, viruses and parasites can sidestep even the best control methodologies, infecting laboratory animal colonies.
- July 16, 2012 | BY
In February of 2012, the Food and Drug Administration (FDA) told makers of cholesterol-lowering statins–a relatively safe drug class that has saved thousands of lives over the past two decades–to add new side effect warnings to their labels. According to the FDA, statin labels must now include the drug’s known association with muscle injury and ...
- July 12, 2012 | BY
When used in a preclinical setting, imaging technologies are helping yield more clinically translatable data to speed drug development.
- July 2, 2012 | BY
In 1969, a neuroradiologist in London, got a call from engineer Godfrey Hounsfield, who, inspired by an idea he dreamed up on vacation, had reconstructed a 3D image of a box by considering it as a series of slices.
- June 20, 2012 | BY
No one is born with talent. Mastery, as it has been shown repeatedly, is developed through purposeful practice.
- June 12, 2012 | BY
Optical Coherence Tomography (OCT) has been used in the clinic since the early 90’s, but has only recently moved into the preclinical space, where it’s used to image the eye of animals in the assessment of therapeutics.