- May 28, 2013 | BY
Recent information indicates that 50% of elderly individuals in the US are osteoporotic and almost 20% of the population is either diabetic or prediabetic.
- May 21, 2013 | BY
In the last decade, the treatment of type 2 Diabetes has evolved with the identification of new therapeutic targets and a better understanding of the disease itself.
- May 13, 2013 | BY
Chronic hyperglycemia is associated with multiple end organ complications and fatty liver. Less often recognized is the long term effect of high glucose on the skeleton.
- May 8, 2013 | BY
If you have been following public health issues you have a pretty good appreciation for the world’s greatest public health problem: the epidemic of obesity-related diseases.
- April 23, 2013 | BY
Conserving animals through proper reduction strategies, while also protecting humans in the long run, can be a difficult balance. A strong commitment to 3Rs helps.
- April 16, 2013 | BY
We’re always looking for better ways to provide good welfare for animals in our care, but how do we always know environmental enrichments improve the welfare of animals?
- April 1, 2013 | BY
The 3Rs proposed by scientists Russell and Burch in the 1950s set the standard for minimizing animal use and maximizing animal well-being in laboratory experimentation.
- March 26, 2013 | BY
The clinical effects of drugs on cardiac repolarization and rhythm, particularly the induction of potentially fatal arrhythmias, such as Torsade de Pointes (TdP), have been increasingly documented over the past two decades. These concerns have given rise to specific regulatory measures, such the ICH S7A, S7B and E14 guidance. These, in turn, have given rise ...
- March 18, 2013 | BY
Jacketed external telemetry (JET) is the latest technology available for collection of continuous electrocardiograms (ECGs) from unrestrained animals. It delivers higher‑quality cardiovascular safety data than predecessor external technologies and has become a premier solution for preclinical research without the use of invasive implantation techniques. After all, Cardiovascular Safety Pharmacology is a logical target as a ...
- March 12, 2013 | BY
Many drugs have either been withdrawn from the market or placed on restricted use due to their (or their metabolites) undesirable ‘off-target’ effects on the heart. An increase in the cardiac action potential duration (APD), caused by a drug blocking the hERG (human ether a go-go) ion channel, can be defined by a prolongation of ...